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Reticular pigmented anomaly of the flexures
Reticular pigmented anomaly of the flexures (also known as "Dark dot disease," and "Dowling–Degos' disease") is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.〔James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. ISBN 0-7216-2921-0.〕 It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.
Dark dot disease is associated with ''KRT5''.
== See also ==
* List of cutaneous conditions
* List of cutaneous conditions caused by mutations in keratins
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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